HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Carbonate → HCID 58052524, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Cyclopropylboronic acid | HCID 2760897 | — |
| Reactant | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl | HCID 11269872 | — |
| Reactant | 6-(N-((S)-5-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-methyl-5-oxopentyl)methylsulfonamido)-5-iodo-N-methyl-2-p-tolylfuro[2,3-b]pyridine-3-carboxamide | HCID 58052533 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 58052524 | HCID 58052524 | — |
Reaction Steps
To 6-(N—((S)-5-((S)-4-benzyl-2-oxooxazolidin-3-yl)-4-methyl-5-oxopentyl)methylsulfonamido)-5-iodo-N-methyl-2-p-tolylfuro[2,3-b]pyridine-3-carboxamide (964 mg, 1.271 mmol) was added a premixed solution of S-Phos (52.2 mg, 0.127 mmol) and Pd(OAc)2 (11.41 mg, 0.051 mmol) in toluene (2.139 mL) Added a premixed solution of 2N SODIUM CARBONATE (12.71 mL, 25.4 mmol) and cyclopropylboronic acid (1637 mg, 19.06 mmol) in toluene (6.42 mL).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324239B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-b666a320576a4514b00fea83985f49e2 |
| Source note | uspto-grants-2012_12 |