Sodium Bicarbonate → HCID 58052426, compound

Participants

Reaction Steps

(S)-((bis(benzyloxy)phosphoryl)oxy)methyl 5-(N-(5-cyclopropyl-3-(methylcarbamoyl)-2-(p-tolyl)furo[2,3-b]pyridin-6-yl)methylsulfonamido)-2-methylpentanoate (10 mg, 0.012 mmol) and Pd—C (10% wt) (1.3 mg) in EtOAc (250 μL) with NaHCO3 (1.045 mg, 0.012 mmol) was placed under N2 and then evacuated and backfilled with H2 and kept under an H2 balloon at RT for 2 hrs (trace COOH side prod.) Filtered through 0.45μ PTFE filter to give (S)-(phosphonooxy)methyl 5-(N-(5-cyclopropyl-3-(methylcarbamoyl)-2-(p-tolyl)furo[2,3-b]pyridin-6-yl)methylsulfonamido)-2-methylpentanoate.

Provenance & Evidence