Water → HCID 58052491, compound

Participants

Reaction Steps

To a solution of 6-(N-(4-hydroxybutyl)methylsulfonamido)-5-iodo-N-methyl-2-p-tolylfuro[2,3-b]pyridine-3-carboxamide (1 eq., 190 mg) in DMSO (1.7 ml) was added triethyl amine (8 eq., 0.38 ml) and pyridine sulfur trioxide (3 eq., 163 mg). The mixture was stirred at room temperature for 1 h. Water was added. The mixture was extracted with EtOAc. The organic layer was washed with water three times, dried over MgSO4 and concentrated to yield the crude title compound which was used in next step without purification.

Provenance & Evidence