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Dichloromethane → 1-((3-Bromofuran-2-yl)methyl)pyrrolidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Pyrrolidine | HCID 31268 | — |
| 反応物 | 3-Bromo-2-furaldehyde | HCID 3367271 | — |
| 反応物 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 1-((3-Bromofuran-2-yl)methyl)pyrrolidine | HCID 71065895 | 65% |
反応手順
To a solution of 3-bromofuran-2-carbaldehyde (1.5 g, 8.57 mmol) and pyrrolidine (1.42 mL, 17.14 mmol) and CH2Cl2 (30 mL) was added sodium triacetoxyborohydride (3.63 g, 17.14 mmol). The mixture was stirred at room temperature for 5 hours. The resulting mixture was diluted with EtOAc (300 mL) and the organic layer was washed with saturated NaHCO3 and brine then dried (Na2SO4), filtered and concentrated. The residue was purified by column chromatography (silica, 0-10% MeOH in CH2Cl2) to afford the sub-title compound (1.26 g, 65%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08324264B1 |
| 出典データセット | uspto-grants-2012_12 |
| ORD ID | ord-9a38e33b6d0f452ea1095034341dbbae |
| 出典メモ | uspto-grants-2012_12 |