Hydrochloric Acid → 5-Amino-1,3,4-thiadiazole-2-sulfonamide

Participants

Reaction Steps

To a solution of N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide (1.0 g, 4.50 mmol) and MeOH (15 mL) was added HCl (2 N, 10 mL). The reaction mixture was heated at reflux for 18 hours and then concentrated under reduced pressure. The residue was purified by column chromatography (silica, 0-10% MeOH in CMA) to afford the sub-title compound (800 mg, 98%).

Provenance & Evidence