Water → 4-(4-Azidophenyl)-5-chlorothiazol-2-amine

HRID 2190315노트

반응식

HRID 2190315 반응식
[N:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([NH2:15])[S:13][CH:14]=2)=[CH:6][CH:5]=1)=[N+:2]=[N-:3].[Cl:16]N1C(=O)CCC1=O.O>CN(C=O)C>[N:1]([C:4]1[CH:9]=[CH:8][C:7]([C:10]2[N:11]=[C:12]([NH2:15])[S:13][C:14]=2[Cl:16])=[CH:6][CH:5]=1)=[N+:2]=[N-:3]

참가 물질

5

반응물 3

HCID 962WaterHCID 31398ChlorosuccinimideHCID 123647384-(4-Azidophenyl)thiazol-2-amine

생성물 1

HCID 575864304-(4-Azidophenyl)-5-chlorothiazol-2-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of 4-(4-azidophenyl)thiazol-2-amine (1.18 g, 5.43 mmol) in DMF (18 mL) at 0° C. was added 1-chloropyrrolidine-2,5-dione (0.746 g, 5.59 mmol). The reaction mixture was warmed to room temperature and stirred for 2 h. The reaction mixture was poured into water (100 mL). The precipitate that formed was collected by filtration, washed with water, and dried under high vacuum to give 4-(4-azidophenyl)-5-chlorothiazol-2-amine.

후처리

  1. customThe precipitate that formed
  2. filtrationwas collected by filtration
  3. washwashed with water
  4. customdried under high vacuum

출처 및 근거

ORD 기록
ord-e74b21f80626420f9e27aa4056707256
출처 데이터셋
uspto-grants-2012_12
특허 번호
US08324396B2

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