Water → HCID 86628122, compound

Participants

Reaction Steps

To a solution of 4-(2-aminothiazol-4-yl)-N-tert-butylbenzenesulfonamide (7.56 g, 24.3 mmol) in DMF (100 mL) at 0° C. was added 1-chloropyrrolidine-2,5-dione (3.30 g, 24.7 mmol). The reaction mixture was warmed to room temperature, stirred for 6 h, and poured into water (500 mL). The solid was collected by filtration, washed with water, and dried under high vacuum to give 4-(2-amino-5-chlorothiazol-4-yl)-N-tert-butylbenzenesulfonamide.

Provenance & Evidence