Dimethylformamide → 3-(Benzo[d]thiazol-2-yl)-1-(3,3-diphenylpropyl)-1-isopropylurea

Participants

Reaction Steps

To a solution of CDI (0.146 g, 0.900 mmol) and DMAP (small catalytic amount) in DCM (1.3 mL) at room temperature was added benzo[d]thiazol-2-amine 3 (0.101 g, 0.672 mmol). The reaction mixture was stirred at room temperature for 1 d and N-isopropyl-3,3-diphenylpropan-1-amine 2 (0.213 g, 0.841 mmol) and DMF (0.5 mL) were added. The reaction mixture was stirred at room temperature for 3 d. Direct purification by flash column chromatography on silica gel (eluted with 50% to 100% DCM in hexanes) gave 3-(benzo[d]thiazol-2-yl)-1-(3,3-diphenylpropyl)-1-isopropylurea 4 (0.190 g) as a white solid.

Provenance & Evidence