HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2190340Generated: November 1, 2026
Potassium Phosphate, Tribasic → HCID 57586421, compound
https://huagongshe.com/reaction/2190340
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 3,3-Diphenylpropylamine | HCID 79698 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Reactant | [2-(4-Bromophenyl)ethoxy](tert-butyl)dimethylsilane | HCID 23254500 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 57586421 | HCID 57586421 | — |
Reaction Steps
To a mixture of copper(I) iodide (0.195 g, 1.02 mmol), (S)-pyrrolidine-2-carboxylic acid (0.223 g, 1.94 mmol), (4-bromophenethoxy)(tert-butyl)dimethylsilane, prepared in the previous step, and 3,3-diphenylpropan-1-amine (3.16 g, 15.0 mmol) was added potassium phosphate (4.27 g, 20.1 mmol), and DMSO (16 mL). The reaction mixture was heated to 90° C. for 1 d and diluted with EtOAc. The organic phase was washed with water (1×), brine (1×), dried over MgSO4, filtered, and concentrated. Purification by flash column chromatography on silica gel (eluted with 5% to 15% EtOAc in hexanes) gave 4-(2-(tert-butyldimethylsilyloxy)ethyl)-N-(3,3-diphenylpropyl)benzenamine 66.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08324396B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-bbcab78cdf044d6195fcaf80384c4977 |
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| Source note | uspto-grants-2012_12 |
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