Tetrabutylammonium Fluoride → HCID 25175473, compound

Participants

Reaction Steps

To a solution of 1-(4-(2-(tert-butyldimethylsilyloxy)ethyl)phenyl)-3-(5-chloro-4-(4-(methylsulfonamido)phenyl)thiazol-2-yl)-1-(3,3-diphenylpropyl)urea (0.289 g, 0.373 mmol) in THF (2 mL) at room temperature was added TBAF (1 M in THF, 1.5 mL, 1.5 mmol). The reaction mixture was stirred at room temperature for 3 h and concentrated. Purification by flash column chromatography on silica gel (eluted with 3% to 10% MeOH in DCM) gave N-(4-(5-chloro-2-(((3,3-diphenylpropyl)(4-(2-hydroxyethyl)phenyl)carbamoyl)amino)-1,3-thiazol-4-yl)phenyl)methanesulfonamide 68. Mass spectrum, calculated for C34H33ClN4O4S2 660.2; found 661.2 (M++1).

Provenance & Evidence