Trifluoroacetic acid → HCID 25175938, compound

Participants

Reaction Steps

To a solution of N-tert-butyl-4-(5-chloro-2-(((3,3-diphenylpropyl)(2-(2-pyridinyl)ethyl)carbamoyl)amino)-1,3-thiazol-4-yl)benzenesulfonamide 84 (0.187 g, 0.272 mmol) in DCM (1 mL) was added anisol (0.20 mL) and TFA (2 mL). The reaction mixture was stirred at room temperature for 1 d and concentrated. The concentrate was diluted with EtOAc and the organic phase was washed with saturated NaHCO3 (1×), brine (1×), dried over MgSO4, filtered, and concentrated. Purification by crystallization from a mixture of DCM and hexanes gave 4-(5-chloro-2-(((3,3-diphenylpropyl)(2-(2-pyridinyl)ethyl)carbamoyl)amino)-1,3-thiazol-4-yl)benzenesulfonamide 85. Mass spectrum, calculated for C32H30ClN5O3S2 631.2; found 632.1 (M++1).

Provenance & Evidence