HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → N-[3-(4-aminophenoxy)phenyl]-3-(1-cyanocyclopropyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3-(1-cyanocyclopropyl)-N-[3-(4-nitrophenoxy)phenyl]benzamide | HCID 67311232 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[3-(4-aminophenoxy)phenyl]-3-(1-cyanocyclopropyl)benzamide | HCID 67312701 | 111.9% |
Reaction Steps
Using 3-(1-cyanocyclopropyl)-N-[3-(4-nitrophenoxy)phenyl]benzamide (5.1 g, 12.7 mmol), tetrahydrofuran (50 mL), methanol (50 mL) and 10% palladium-carbon (455.9 mg) as starting materials, and in the same manner as in Example A12(iii), the title compound (5.25 g) was obtained as a colorless amorphous substance. The obtained compound was used in the next reaction without a further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324395B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-e3444e1de7a74ec9af6574d0685ac5df |
| Source note | uspto-grants-2012_12 |