4-Methoxy-4-(3-hydroxy-trans-prop-1-enyl)tetrahydropyran → 4-Methoxy-4-(3-hydroxypropyl)tetrahydropyran

HRID 21904Notes

Reaction equation

HRID 21904 reaction equation
[CH3:1][O:2][C:3]1(/[CH:9]=[CH:10]/[CH2:11][OH:12])[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1>[Pd]>[CH3:1][O:2][C:3]1([CH2:9][CH2:10][CH2:11][OH:12])[CH2:8][CH2:7][O:6][CH2:5][CH2:4]1

Participants

3

Reactant 1

HCID 151990644-Methoxy-4-(3-hydroxy-trans-prop-1-enyl)tetrahydropyran

Product 1

HCID 199309254-Methoxy-4-(3-hydroxypropyl)tetrahydropyran

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The desired compound is prepared by catalytic hydrogenolysis of 4-methoxy-4-(3-hydroxy-trans-prop-1-enyl) tetrahydropyran, prepared as in Example 1, steps 1-4, using palladium on calcium carbonate poisoned with lead according to the method of U.S. Pat. No. 5,268,379, Example 5.

Sources & evidence

ORD record
ord-4585bd61baae491283d6043f906b4cff
Source dataset
uspto-grants-1995_06
Patent number
US05426111

Reaction notes

Loading…