HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-(1-Cyano-1-methylethyl)benzoyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-(2-Cyanopropan-2-yl)benzoic acid | HCID 57149538 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(1-Cyano-1-methylethyl)benzoyl chloride | HCID 86631981 | — |
Reaction Steps
To a solution of 3-(1-cyano-1-methylethyl)benzoic acid (5.00 g, 26.4 mmol) produced in Example A7(ii) in tetrahydrofuran (50 mL) were added N,N-dimethylformamide (40 μL) and oxalyl chloride (3.20 mL, 36.5 mmol), and the mixture was stirred at room temperature for 1.5 hr. The reaction mixture was concentrated under reduced pressure to give 3-(1-cyano-1-methylethyl)benzoyl chloride.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324395B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-b0eae4906ad441c49a502de3c428d827 |
| Source note | uspto-grants-2012_12 |