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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2190436Generated: November 1, 2026

p-Fluoronitrobenzene → 3-(1-cyano-1-methylethyl)-N-[4-methyl-3-(4-nitrophenoxy)phenyl]benzamide

https://huagongshe.com/reaction/2190436

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-FluoronitrobenzeneHCID 9590—
ReactantPotassium CarbonateHCID 11430—
Reactant3-(1-cyano-1-methylethyl)-N-(3-hydroxy-4-methylphenyl)benzamideHCID 67313470—
Product3-(1-cyano-1-methylethyl)-N-[4-methyl-3-(4-nitrophenoxy)phenyl]benzamideHCID 67312245—

Reaction Steps

Using 3-(1-cyano-1-methylethyl)-N-(3-hydroxy-4-methylphenyl)benzamide (1.47 g, 5.0 mmol), 1-fluoro-4-nitrobenzene (0.77 g, 5.5 mmol) and potassium carbonate (0.69 g, 5.0 mmol), and in the same manner as in Example A25(iii), the title compound (2.08 g, quantitatively) was obtained as a yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08324395B2
Source datasetuspto-grants-2012_12
ORD IDord-f7cba86e3dc74ed29808b708134c1082
Source noteuspto-grants-2012_12