Sodium Hydroxide → 3-(1-cyanocyclopropyl)-N-[3-({2-[(hydroxyacetyl)amino]-1,3-benzothiazol-6-yl}oxy)-4-methylphenyl]benzamide

Participants

Reaction Steps

Using N-{3-[(2-amino-1,3-benzothiazol-6-yl)oxy]-4-methylphenyl}-3-(1-cyanocyclopropyl)benzamide (0.11 g, 0.25 mmol) produced in Example A35(iv), 2-chloro-2-oxoethyl acetate (0.27 g, 2.0 mmol), and 8N aqueous sodium hydroxide solution (1 mL), and in the same manner as in Example A30, the title compound (17 mg, 14%) was obtained as a pale-yellow powder.

Provenance & Evidence