HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2-Dibromoethane → Methyl 2-chloro-3-(1-cyanocyclopropyl)benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2-Dibromoethane | HCID 7839 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 57386575 | HCID 57386575 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl 2-chloro-3-(1-cyanocyclopropyl)benzoate | HCID 67311674 | 35% |
Reaction Steps
Using Methyl 2-chloro-3-(cyanomethyl)benzoate (2.00 g, 9.54 mmol), sodium hydride (60% in oil, 1.14 g, 28.6 mmol), 1,2-dibromoethane (1.18 mL, 14.3 mmol) and dimethyl sulfoxide (20 mL) as starting materials, and in the same manner as in Example A1(ii), the title compound (787 mg, 35%) was obtained as a colorless oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324395B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-0c20a0dedd004142a9cd4dc593376431 |
| Source note | uspto-grants-2012_12 |