HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 2-Chloro-3-(1-cyanocyclopropyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Methyl 2-chloro-3-(1-cyanocyclopropyl)benzoate | HCID 67311674 | — |
| Solvent | Water | HCID 962 | — |
| Product | 2-Chloro-3-(1-cyanocyclopropyl)benzoic acid | HCID 66810306 | 71.1% |
Reaction Steps
Using methyl 2-chloro-3-(1-cyanocyclopropyl)benzoate (684 mg, 2.90 mmol), lithium hydroxide•monohydrate (207 mg, 4.93 mmol), tetrahydrofuran (10 mL), methanol (3 mL) and water (3 mL) as starting materials, and in the same manner as in Example A1(iii), the title compound (457 mg, 71%) was obtained as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324395B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-b0f04afce995453b9ab0e5406199eecb |
| Source note | uspto-grants-2012_12 |