HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → HCID 86655400, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 3-(2-Methylbut-3-yn-2-yl)benzoic acid | HCID 86227414 | — |
| Reactant | N-[6-(3-aminophenoxy)-1,3-benzothiazol-2-yl]acetamide | HCID 86655397 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86655400 | HCID 86655400 | 22.3% |
Reaction Steps
Using N-[6-(3-aminophenoxy)-1,3-benzothiazol-2-yl]acetamide (160 mg, 0.534 mmol) produced in Example A40(x), 3-(1,1-dimethylprop-2-yn-1-yl)benzoic acid (201 mg, 1.07 mmol), tetrahydrofuran (4 mL), N,N-dimethylformamide (10 μL), oxalyl chloride (170 mg, 1.34 mmol) and N,N-dimethylformamide (4 mL), and in the same manner as in Example A40(xi), the title compound (56 mg, 22%) was obtained as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324395B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-2ab5819bb89d4dc68af946d646afcc41 |
| Source note | uspto-grants-2012_12 |