HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → N-(3-{[2-(acetylamino)-1,3-benzothiazol-6-yl]oxy}phenyl)-3-cyanobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | 3-Cyanobenzoic acid | HCID 15875 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | N-[6-(3-aminophenoxy)-1,3-benzothiazol-2-yl]acetamide | HCID 86655397 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | N-(3-{[2-(acetylamino)-1,3-benzothiazol-6-yl]oxy}phenyl)-3-cyanobenzamide | HCID 86655405 | 55.5% |
Reaction Steps
Using N-[6-(3-aminophenoxy)-1,3-benzothiazol-2-yl]acetamide (160 mg, 0.534 mmol) produced in Example A40(x), 3-cyanobenzoic acid (157 mg, 1.07 mmol), tetrahydrofuran (4 mL), N,N-dimethylformamide (10 μL), oxalyl chloride (170 mg, 1.34 mmol) and N,N-dimethylformamide (4 mL), and in the same manner as in Example A40(xi), the title compound (127 mg, 55%) was obtained as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324395B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-c996750b9eac4033861c7b6b67e9efdf |
| Source note | uspto-grants-2012_12 |