Tert-butyl [3-(3-amino-4-nitrophenoxy)phenyl]carbamate → Tert-butyl [3-(3,4-diaminophenoxy)phenyl]carbamate

Participants

Reaction Steps

tert-Butyl [3-(3-amino-4-nitrophenoxy)phenyl]carbamate (5.51 g, 15.6 mmol) and 10% palladium-carbon (875 mg) were dissolved in tetrahydrofuran (20 mL) and methanol (100 mL), and the mixture was stirred at room temperature for 18 hr under a hydrogen atmosphere (3 atm). Palladium-carbon was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (5.17 g) as a purple amorphous substance.

Provenance & Evidence