HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloronicotinoyl Chloride → 6-Chloro-N-(4-chloro-3-iodo-phenyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloronicotinoyl Chloride | HCID 2782165 | — |
| Reactant | 4-Chloro-3-iodoaniline | HCID 21874954 | — |
| Reactant | 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide | HCID 59318138 | — |
| Product | 6-Chloro-N-(4-chloro-3-iodo-phenyl)-nicotinamide | HCID 59318102 | — |
Reaction Steps
6-Chloro-N-(4-chloro-3-iodo-phenyl)-nicotinamide was prepared from 4-chloro-3-iodo aniline (perpared as described in WO03/062241) and 6-chloronicotinoyl chloride following a procedure similar to the one described in the synthesis of 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide, above. The product was isolated after suspension in small volume of CH2Cl2 and filtration. HRMS m/z calcd for C12H7N2OCl2I [M+H]+: 392.9053. Found: 392.9054.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-c48c4a963ef7480b98e2dd78629b29e1 |
| Source note | uspto-grants-2012_12 |