HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloronicotinoyl Chloride → N-(4-tert-Butyl-pyrimidin-2-yl)-6-chloro-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloronicotinoyl Chloride | HCID 2782165 | — |
| Reactant | 4-tert-Butylpyrimidin-2-amine | HCID 12450631 | — |
| Reactant | 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide | HCID 59318138 | — |
| Product | N-(4-tert-Butyl-pyrimidin-2-yl)-6-chloro-nicotinamide | HCID 59318000 | — |
Reaction Steps
N-(4-tert-Butyl-pyrimidin-2-yl)-6-chloro-nicotinamide was prepared from 4-tert-butyl-pyrimidin-2-ylamine (prepared as described in J. Org. Chem. 1977, 221) and 6-chloronicotinoyl chloride following a procedure similar to the one described in the synthesis of 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide, above. The product was isolated after silica gel purification with 20-40% EtOAc in hexanes gradient followed by suspension in hexanes and filtration. HRMS m/z calcd for C14H15N4OCl [M+H]+: 291.1007. Found: 291.1007.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-d4ebcb040dd343938ff269a214625452 |
| Source note | uspto-grants-2012_12 |