HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyaniline → 6-Chloro-N-(3-methoxyphenyl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyaniline | HCID 10824 | — |
| Reactant | 6-Chloronicotinoyl Chloride | HCID 2782165 | — |
| Reactant | 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide | HCID 59318138 | — |
| Product | 6-Chloro-N-(3-methoxyphenyl)nicotinamide | HCID 18419424 | — |
Reaction Steps
6-Chloro-N-(3-methoxy-phenyl)-nicotinamide was prepared from 3-methoxyaniline and 6-chloronicotinoyl chloride following a procedure similar to the one described in the synthesis of 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide, above. The product was isolated after precipitation out of small volume of CH2Cl2 with hexanes. HRMS m/z calcd for C13H11N2OCl [M+H]+: 263.0582. Found: 263.0581.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-e6389d0b4a3b438d9d5c8e3a8b6a3984 |
| Source note | uspto-grants-2012_12 |