HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Fluoro-4-(trifluoromethyl)aniline → 6-Chloro-N-(2-fluoro-4-trifluoromethyl-phenyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Fluoro-4-(trifluoromethyl)aniline | HCID 2737674 | — |
| Reactant | 6-Chloronicotinoyl Chloride | HCID 2782165 | — |
| Reactant | 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide | HCID 59318138 | — |
| Product | 6-Chloro-N-(2-fluoro-4-trifluoromethyl-phenyl)-nicotinamide | HCID 59318076 | — |
Reaction Steps
6-Chloro-N-(2-fluoro-4-trifluoromethyl-phenyl)-nicotinamide was prepared from 2-fluoro-4-trifluoromethyl aniline and 6-chloronicotinoyl chloride following a procedure similar to the one described in the synthesis of 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide, above. The product was isolated after precipitation out of a small volume of CH2Cl2 with hexanes. HRMS m/z calcd for C13H7N2OClF4 [M+H]+: 319.0256. Found: 319.0255.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-edfa1a8f7b2a4ca9a94fe4cf1eb271ef |
| Source note | uspto-grants-2012_12 |