HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-4-methoxyaniline → 6-Chloro-N-(4-methoxy-2-methyl-phenyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-4-methoxyaniline | HCID 7610 | — |
| Reactant | 6-Chloronicotinoyl Chloride | HCID 2782165 | — |
| Reactant | 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide | HCID 59318138 | — |
| Product | 6-Chloro-N-(4-methoxy-2-methyl-phenyl)-nicotinamide | HCID 9856843 | — |
Reaction Steps
6-Chloro-N-(4-methoxy-2-methyl-phenyl)-nicotinamide was prepared from 4-methoxy-2-methyl aniline and 6-chloronicotinoyl chloride following a procedure similar to the one described in the synthesis of 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide, above. The product was isolated after precipitation out of a small volume of CH2Cl2 with hexanes. HRMS m/z calcd for C14H13N2O2Cl [M+H]+: 277.0739. Found: 277.0738.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-ad92a06b152e4e96acd6141cca275a71 |
| Source note | uspto-grants-2012_12 |