6-Chloronicotinoyl Chloride → 6-Chloro-N-(3,2',4'-trifluoro-biphenyl-4-yl)-nicotinamide

Participants

Reaction Steps

6-Chloro-N-(3,2′,4′-trifluoro-biphenyl-4-yl)-nicotinamide was prepared from 3,2′,4′-trifluoro-biphenyl-4-yl amine and 6-chloronicotinoyl chloride following a procedure similar to the one described in the synthesis of 6-chloro-N-(4-iodo-3-methyl-phenyl)-nicotinamide, above. The product was isolated after a silica gel column chromatography with 0-30% EtOAc in hexanes. H1 NMR (300 MHz, chloroform-d) d ppm 6.91 (m, 2H), 7.15 (apparent t, J=8.1 Hz, 1H), 7.24-7.1 (m, 3H), 7.95 (dd, J=10.5 8.1 Hz, 2H), 8.69 (d, J=2.1 Hz, 2H).

Provenance & Evidence