HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-(3-tert-Butyl-phenyl)-4-piperidin-4-yl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 4-[4-(3-Tert-butyl-phenylcarbamoyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester | HCID 59318012 | — |
| Reactant | N-(4-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamide | HCID 59318019 | — |
| Product | N-(3-tert-Butyl-phenyl)-4-piperidin-4-yl-benzamide | HCID 59317976 | — |
Reaction Steps
N-(3-tert-Butyl-phenyl)-4-piperidin-4-yl-benzamide was synthesized by the TFA deprotection of 4-[4-(3-tert-butyl-phenylcarbamoyl)-phenyl]-piperidine-1-carboxylic acid tert-butyl ester in a manner similar to the one described in the synthesis of N-(4-tert-butyl-phenyl)-6-piperazin-1-yl-nicotinamide. LCMS calcd for C22H28N2O (m/e) 336, obsd 337 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-42035ea34fb84e309a1cc08e42eba06e |
| Source note | uspto-grants-2012_12 |