4-Benzylbenzoate piperidine 4-ethyl benzoate → 4-Ethylbenzoate piperidine-4-benzoic acid

Participants

Reaction Steps

A mixture of 4-benzylbenzoate-piperidine-4-ethyl benzoate (200 mg, 0.45 mmol) 10% Pd/C (48 mg) in EtOH/EtOAc (1:1) was hydrogenated under 1 atm of hydrogen for 2 h. Then followed addition of additional portion of 10% Pd/C (100 mg) and the mixture was hydrogenated again under 1 atm of hydrogen for 5 h more. Followed filtration, the solids were washed with THF and DMF. The combined filtrate was concentrated to afford the product (130 mg, Yield: 82%).

Provenance & Evidence