HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Phenylpiperidin-4-ol → 4-Hydroxy-4-phenyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Phenylpiperidin-4-ol | HCID 96387 | — |
| Reactant | 6-chloro-N-(5-methyl-4-phenyl-1,3-thiazol-2-yl)pyridine-3-carboxamide | HCID 3379941 | — |
| Reactant | 4-hydroxy-4-phenyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid (5-methyl-4-phenyl-thiazol-2-yl)-amide | HCID 59317978 | — |
| Reactant | 4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid (5-methyl-4-phenyl-thiazol-2-yl)-amide | HCID 59317981 | — |
| Product | 4-Hydroxy-4-phenyl-3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl | HCID 86641502 | — |
Reaction Steps
With a method similar to that used for the preparation of 4-(3-trifluoromethyl-phenyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carboxylic acid (5-methyl-4-phenyl-thiazol-2-yl)-amide, 4-hydroxy-4-phenyl-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carboxylic acid (5-methyl-4-phenyl-thiazol-2-yl)-amide was prepared from 6-chloro-N-(5-methyl-4-phenyl-thiazol-2-yl)-nicotinamide and 4-phenyl-piperidin-4-ol. LCMS calcd for C27H26N4O2S (m/e) 470, obsd 471 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-bd5ad1c2c6e642459ab88f9ab2b2e2f2 |
| Source note | uspto-grants-2012_12 |