HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Iodo-p-toluidine → 1-[4-(3-Iodo-4-methyl-phenylcarbamoyl)-phenyl]-piperidine-4-carboxylic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Iodo-p-toluidine | HCID 118889 | — |
| Reactant | 4-[4-(Ethoxycarbonyl)piperidin-1-YL]benzoic acid | HCID 19063864 | — |
| Reactant | 1-[4-(3-tert-Butyl-phenylcarbamoyl)-phenyl]-piperidine-4-carboxylic acid ethyl ester | HCID 59318053 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-[4-(3-Iodo-4-methyl-phenylcarbamoyl)-phenyl]-piperidine-4-carboxylic acid ethyl ester | HCID 59317989 | — |
Reaction Steps
1-[4-(3-Iodo-4-methyl-phenylcarbamoyl)-phenyl]-piperidine-4-carboxylic acid ethyl ester was prepared from 3-iodo-4-methyl aniline and 1-(4-carboxy-phenyl)-piperidine-4-carboxylic acid ethyl ester following a procedure similar to the one described in the synthesis of 1-[4-(3-tert-Butyl-phenylcarbamoyl)-phenyl]-piperidine-4-carboxylic acid ethyl ester above. The product was isolated after a silica gel column with a 20-50% Et2O in hexanes gradient followed by a 50% EtOAc in hexanes elution. HRMS m/z calcd for C22H25N2O3I [M+H]+: 493.0983. Found: 493.0982.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-58d942c1cc1b43cca756ea7a22aefb55 |
| Source note | uspto-grants-2012_12 |