HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-piperidinecarboxylate → HCID 59318009, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-piperidinecarboxylate | HCID 70770 | — |
| Reactant | 4-Piperidinecarboxylic acid, 1-(2-pyridinyl)-, ethyl ester | HCID 3815618 | — |
| Reactant | HCID 59318066 | HCID 59318066 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 59318009 | HCID 59318009 | — |
Reaction Steps
5′-(1-Methyl-1H-indol-6-ylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid ethyl ester was prepared from 6-chloro-N-(1-methyl-1H-indol-6-yl)-nicotinamide and ethyl isonipecotate following a procedure similar to the one described in the synthesis of 5′43-iodo-4-methyl-phenylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4 carboxylic acid ethyl ester above. The product was isolated by silica gel column purification with 20-40% EtOAc in hexanes gradient. HRMS m/z calcd for C23H26N4O3 [M+H]+: 407.2078. Found: 407.2076.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-c07134fb51ae43068893d8c11662afed |
| Source note | uspto-grants-2012_12 |