tert-Butylsulfonamide → N-(1-Ethyl-1H-indol-6-yl)-4-[4-(2-methyl-propane-2-sulfonylaminocarbonyl)-piperidin-1-yl]-benzamide

Participants

Reaction Steps

N-(1-Ethyl-1H-indol-6-yl)-4-[4-(2-methyl-propane-2-sulfonylaminocarbonyl)-piperidin-1-yl]-benzamide was prepared form 1-[4-(1-ethyl-1H-indol-6-ylcarbamoyl)-phenyl]-piperidine-4-carboxylic acid and t-butyl sulfonamide in a manner similar to the one described in the synthesis of 4-(2-methyl-propane-2-sulfonylaminocarbonyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carboxylic acid (4-iodo-3-methyl-phenyl)-amide. The product was isolated after a silica gel column purification with 50-100% Et2O in hexanes to 50-100% EtOAc in hexane gradient. HRMS m/z calcd for C27H34N4O4S [M+H]+: 511.2374. Found: 511.2372.

Provenance & Evidence