tert-Butylsulfonamide → 3,4,5,6-tetrahydro-2H-[1,2']bipyridinyl-5'-carboxylic acid (1-ethyl-1H-indol-6-yl)-amide

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Reaction Steps

4-Methyl-propane-2-sulfonylaminocarbonyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carboxylic acid (1-ethyl-1H-indol-6-yl)-amide was synthesized by the ECU coupling of 5″-ethyl-1H-indol-6-ylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid (prepared by the hydrolysis of 5′-(1-ethyl-1H-indol-6-ylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid ethyl ester with LiOH monohydrate as described in the synthesis of 5′44-iodo-3-methyl-phenylcarbamoyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-4-carboxylic acid above.) with t-butyl sulfonamide in a manner similar to the one described in the synthesis of 442-methyl-propane-2-sulfonylaminocarbonyl)-3,4,5,6-tetrahydro-2H-[1,2′]bipyridinyl-5′-carboxylic acid (4-iodo-3-methyl-phenyl)-amide. LCMS calcd for C26H33N5O4S (m/e) 511, obsd 512 (M+H).

Provenance & Evidence