HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-(piperazin-1-yl)benzoate → 4-{4-[5-(3-Chloro-4-iodo-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-(piperazin-1-yl)benzoate | HCID 2761178 | — |
| Reactant | 6-Chloro-N-(3-chloro-4-iodo-phenyl)-nicotinamide | HCID 59318035 | — |
| Reactant | 4-{4-[5-(3-Iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid ethyl ester | HCID 59318063 | — |
| Product | 4-{4-[5-(3-Chloro-4-iodo-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid ethyl ester | HCID 59318027 | — |
Reaction Steps
4-{4-[5-(3-Chloro-4-iodo-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid ethyl ester was prepared from 6-chloro-N-(3-chloro-4-Iodo-phenyl)-nicotinamide and 4-(piperazin-1-yl)-benzoic acid ethyl ester following a method similar to the one described in the synthesis of 4-{4-[5-(3-iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid ethyl ester above. HRMS m/z calcd for C25H24N4O3ClI [M+H]+: 591.0655. Found: 591.0657.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-8f3bc293332e44ab9f2a9171db600417 |
| Source note | uspto-grants-2012_12 |