Diisopropylethylamine → HCID 68591870, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of N-indan-5-yl-4-piperazin-1-yl-benzamide (80 mg) and 2-chloropyridine-5-carboxylic acid ethyl ester (220 mg) in THF (4 mL) was added diisopropylethylamine (0.1 mL). The solution was heated in a microwave at 170° C. for 2 hrs. The crystalline precipitate was filtered and washed with THF to give 6-{4-[4-(indan-5-ylcarbamoyl)-phenyl]-piperazin-1-yl}-nicotinic acid ethyl ester (62 mg, Yield: 53%). LCMS calc for C28H30N4O3 (m/e) 470, obsd 471 (M+H).

Provenance & Evidence