HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-{4-[5-(3-tert-Butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid → 4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-phenyl]-piperazin-1-yl}-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-{4-[5-(3-tert-Butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid | HCID 46201976 | — |
| Reactant | 4-{4-[4-(3-Tert-butyl-phenylcarbamoyl)-phenyl}-piperazin-1-yl]-benzoic acid ethyl ester | HCID 59318150 | — |
| Product | 4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-phenyl]-piperazin-1-yl}-benzoic acid | HCID 46201977 | — |
Reaction Steps
4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-phenyl]-piperazin-1-yl}-benzoic acid was prepared from the LiOH monohydrate hydrolysis of 4-{4-[4-(3-tert-butyl-phenylcarbamoyl)-phenyl}-piperazin-1-yl]-benzoic acid ethyl ester following a method similar to the one described in the synthesis of 4-{4-[5-(3-tert-butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid above. HRMS m/z calcd for C28H31N3O3 [M+H]+: 458.2438. Found: 458.2439.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-54bbd7125b8543b2aec407930916c7aa |
| Source note | uspto-grants-2012_12 |