反应详情

4-{4-[5-(3-Fluoro-5-iodo-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid was prepared by the hydrolysis of 4-{4-[5-(3-fluoro-5-iodo-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid ethyl ester with LiOH monohydrate in manner similar to the one described in the synthesis of 4-{4-[5-(3-tert-butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid, above. The product was obtained after suspension in small volume of EtOAc, filtration and a wash with CH3CN. HRMS m/z calcd for C23H20N4O3FI [M+H]+: 547.0637. Found: 547.0634.

1. customThe product was obtained after suspension
2. filtrationin small volume of EtOAc, filtration
3. washa wash with CH3CN