HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(4-tert-butylphenyl)-6-chloronicotinamide → 4-{4-[5-(4-tert-Butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(4-tert-butylphenyl)-6-chloronicotinamide | HCID 4811429 | — |
| Reactant | 4-Piperazin-1-yl-benzoic acid benzyl ester | HCID 53921663 | — |
| Reactant | 4-[4-(5-Phenylcarbamoyl-pyridin-2-yl)-piperazin-1-yl]-benzoic acid | HCID 59317983 | — |
| Product | 4-{4-[5-(4-tert-Butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid | HCID 46202973 | — |
Reaction Steps
4-{4-[5-(4-tert-Butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid was prepared from 4-piperazin-1-yl-benzoic acid benzyl ester and N-(4-tert-butyl-phenyl)-6-chloro-nicotinamide with a method similar to the one described in the synthesis of 4-[4-(5-phenylcarbamoyl-pyridin-2-yl)-piperazin-1-yl]-benzoic acid above. HRMS m/z calcd for C27H30N4O3 [M+H]+: 459.2391. Found: 459.2390.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-8cda249bb6864cf4acea631b3cb32567 |
| Source note | uspto-grants-2012_12 |