HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloro-N-(3-methoxyphenyl)nicotinamide → 4-{4-[5-(3-Methoxy-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloro-N-(3-methoxyphenyl)nicotinamide | HCID 18419424 | — |
| Reactant | 4-Piperazin-1-yl-benzoic acid benzyl ester | HCID 53921663 | — |
| Reactant | 4-[4-(5-Phenylcarbamoyl-pyridin-2-yl)-piperazin-1-yl]-benzoic acid | HCID 59317983 | — |
| Product | 4-{4-[5-(3-Methoxy-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid | HCID 59318185 | — |
Reaction Steps
4-{4-[5-(3-Methoxy-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid was prepared from 4-piperazin-1-yl-benzoic acid benzyl ester and 6-chloro-N-(3-methoxy-phenyl)-nicotinamide with a method similar to the one described in the synthesis of 4-[4-(5-phenylcarbamoyl-pyridin-2-yl)-piperazin-1-yl]-benzoic acid above. HRMS m/z calcd for C24H24N4O4 [M+H]+: 433.1871. Found: 433.1868.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-0da70130f2f84259a9e8229c2b48ddae |
| Source note | uspto-grants-2012_12 |