HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Piperazin-1-yl-benzoic acid benzyl ester → 4-{4-[5-(2-Fluoro-4-trifluoromethyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Piperazin-1-yl-benzoic acid benzyl ester | HCID 53921663 | — |
| Reactant | 4-[4-(5-Phenylcarbamoyl-pyridin-2-yl)-piperazin-1-yl]-benzoic acid | HCID 59317983 | — |
| Reactant | 6-Chloro-N-(2-fluoro-4-trifluoromethyl-phenyl)-nicotinamide | HCID 59318076 | — |
| Product | 4-{4-[5-(2-Fluoro-4-trifluoromethyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid | HCID 67376485 | — |
Reaction Steps
4-{4-[5-(2-Fluoro-4-trifluoromethyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid was prepared from 4-piperazin-1-yl-benzoic acid benzyl ester and 6-chloro-N-(2-fluoro-4-trifluoromethyl-phenyl)-nicotinamide with a method similar to the one described in the synthesis of 4-[4-(5-phenylcarbamoyl-pyridin-2-yl)-piperazin-1-yl]-benzoic acid above. HRMS m/z calcd for C24H20N4O3F4 [M+H]+: 489.1545. Found: 489.1543.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-3063218005f948428ed11ac3088fb101 |
| Source note | uspto-grants-2012_12 |