HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromobenzoic acid → 4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-2-chloro-phenyl]-piperazin-1-yl}-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromobenzoic acid | HCID 11464 | — |
| Reactant | N-(3-tert-Butyl-phenyl)-3-chloro-4-piperazin-1-yl-benzamide | HCID 59318031 | — |
| Reactant | 4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-2-fluoro-phenyl]-piperazin-1-yl}-benzoic acid | HCID 59318193 | — |
| Product | 4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-2-chloro-phenyl]-piperazin-1-yl}-benzoic acid | HCID 59318192 | — |
Reaction Steps
4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-2-chloro-phenyl]-piperazin-1-yl}-benzoic acid was synthesized by the coupling of N-(3-tert-Butyl-phenyl)-3-chloro-4-piperazin-1-yl-benzamide and 4-bromo benzoic acid in a manner similar to the one described in the synthesis of 4-{4-[4-(3-tert-butyl-phenylcarbamoyl)-2-fluoro-phenyl]-piperazin-1-yl}-benzoic acid above. LCMS calcd for C28H30ClN3O3 (m/e) 491, obsd 490 (M−H)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-e9fefc5634b84e81b1283247312707b7 |
| Source note | uspto-grants-2012_12 |