HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromobenzoic acid → 3-{4-[5-(3-tert-Butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromobenzoic acid | HCID 11456 | — |
| Reactant | N-(3-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamide | HCID 59318114 | — |
| Reactant | 4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-2-fluoro-phenyl]-piperazin-1-yl}-benzoic acid | HCID 59318193 | — |
| Product | 3-{4-[5-(3-tert-Butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid | HCID 59318054 | — |
Reaction Steps
3-{4-[5-(3-tert-Butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-benzoic acid was synthesized from N-(3-tert-butyl-phenyl)-6-piperazin-1-yl-nicotinamide and 3-bromo benzoic acid in a manner similar to the one described in the synthesis of 4-{4-[4-(3-tert-butyl-phenylcarbamoyl)-2-fluoro-phenyl]-piperazin-1-yl}-benzoic acid above. LCMS calcd for C27H30N4O3 (m/e) 458, obsd 459 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-0c96da5b7f424068b951d7d019737b28 |
| Source note | uspto-grants-2012_12 |