HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Chloronicotinic acid → HCID 59318094, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Chloronicotinic acid | HCID 79222 | — |
| Reactant | N-(3-tert-Butyl-phenyl)-6-piperazin-1-yl-nicotinamide | HCID 59318114 | — |
| Reactant | 4-{4-[4-(3-tert-Butyl-phenylcarbamoyl)-2-fluoro-phenyl]-piperazin-1-yl}-benzoic acid | HCID 59318193 | — |
| Product | HCID 59318094 | HCID 59318094 | — |
Reaction Steps
6-{4-[5-(3-tert-Butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazin-1-yl}-nicotinic acid was synthesized from N-(3-tert-butyl-phenyl)-6-piperazin-1-yl-nicotinamide and 6-chloro nicotinic acid in a manner similar to the one described in the synthesis of 4-{4-[4-(3-tert-butyl-phenylcarbamoyl)-2-fluoro-phenyl]-piperazin-1-yl}-benzoic acid above. LCMS calcd for C26H29N5O3 (m/e) 459, obsd 460 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-b70a22a6a7cd44289c3d7bfd6bc63675 |
| Source note | uspto-grants-2012_12 |