4-Methoxy-2-aminobenzothiazole → HCID 59318111, compound

HRID 2190634Notes

Reaction equation

HRID 2190634 reaction equation
FC1C=CC(C(F)(F)F)=CC=1[NH:12][C:13]([C:15]1[CH:20]=[CH:19][C:18]([N:21]2[CH2:26][CH2:25][N:24]([C:27]3[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=3)[CH2:23][CH2:22]2)=[CH:17][CH:16]=1)=[O:14].C(C1SC(NC(C2C=CC(N3CCN(C4C=CC(C(O)=O)=CC=4)CC3)=CC=2)=O)=NC=1C1C=CC=CC=1)C.C(OC(=O)C1C=CC(N2CCN(C3C=CC(C(O)=O)=CC=3)CC2)=CC=1)(C)(C)C.[CH3:101][O:102][C:103]1[C:108]2[N:109]=[C:110](N)[S:111][C:107]=2[CH:106]=[CH:105][CH:104]=1>>[CH3:101][O:102][C:103]1[C:108]2[N:109]=[C:110]([NH:12][C:13]([C:15]3[CH:20]=[CH:19][C:18]([N:21]4[CH2:22][CH2:23][N:24]([C:27]5[CH:35]=[CH:34][C:30]([C:31]([OH:33])=[O:32])=[CH:29][CH:28]=5)[CH2:25][CH2:26]4)=[CH:17][CH:16]=3)=[O:14])[S:111][C:107]=2[CH:106]=[CH:105][CH:104]=1

Participants

5

Reactant 4

HCID 216224-Methoxy-2-aminobenzothiazoleHCID 46202647HCID 46202647, compoundHCID 59318029HCID 59318029, compoundHCID 59318058HCID 59318058, compound

Product 1

HCID 59318111HCID 59318111, compound

Procedure

With the same method as described for the preparation of 4-{4-[4-(2-fluoro-5-trifluoromethyl-phenylcarbamoyl)-phenyl]-piperazin-1-yl}-benzoic acid, 4-{4-[4-(5-ethyl-4-phenyl-thiazol-2-ylcarbamoyl)-phenyl]-piperazin-1-yl}-benzoic acid was prepared from 4-[4-(4-carboxyphenyl)-piperazin-1-yl]-benzoic acid tert-butyl ester and 4-methoxy-benzothiazol-2-ylamine. LCMS calc for C26H24N4O4S (m/e) 488, obsd 489 (M+H).

Sources & evidence

ORD record
ord-8c96904c279a4098b75757bf9c7c279d
Source dataset
uspto-grants-2012_12
Patent number
US08324385B2

Reaction notes

Loading…