(3S)-(-)-3-(tert-Butoxycarbonylamino)pyrrolidine → HCID 59318008, compound

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{(S)-1-[5-(3-Iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester was prepared from 6-chloro-N-(3-iodo-4-methyl-phenyl)-nicotinamide and (−)-(S)-3-(Boc-amino)pyrrolidine following a method similar to the one described in the synthesis of 4-[5-(3-iodo-4-methyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carboxylic acid tert-butyl ester above. The product was isolated after a silica gel column purification and a precipitation out of THF with excess of hexanes. HRMS m/z calcd for C22H27N4O3I [M+H]+: 523.1201. Found: 523.1201.

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