反应详情

4-[4-(3-Iodo-4-methyl-phenylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester was prepared from 3-iodo-4-methyl aniline and 4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester in a manner similar to the one described in the synthesis of 4-[4-(3-tert-butyl-phenylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester, above. The product was isolated after a silica gel purification with 10-30% Et2O in toluene. HRMS m/z calcd for C23H28N3O3I [M+H]: 522.1248. Found: 522.1246.

1. customThe product was isolated
2. customafter a silica gel purification with 10-30% Et2O in toluene