HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Naphthylamine → 4-[4-(Naphthalen-2-ylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Naphthylamine | HCID 7057 | — |
| Reactant | 4-[4-(tert-Butoxycarbonyl)piperazin-1-yl]benzoic acid | HCID 2795508 | — |
| Reactant | 4-[4-(3-Tert-butyl-phenylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 59318017 | — |
| Product | 4-[4-(Naphthalen-2-ylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester | HCID 59317992 | — |
Reaction Steps
4-[4-(Naphthalen-2-ylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester was synthesized from 4-(4-carboxy-phenyl)-piperazine-1-carboxylic acid tert-butyl ester and naphthalen-2-ylamine in a manner similar to the one described in the synthesis of 4-[4-(3-tert-butyl-phenylcarbamoyl)-phenyl]-piperazine-1-carboxylic acid tert-butyl ester, above. LCMS calcd for C26H29N3O3 (m/e) 431, obsd 432 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-d22c987d16b845d198fb9463cc895fe2 |
| Source note | uspto-grants-2012_12 |