HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanecarboxylic acid → 6-(4-Cyclopropanecarbonyl-piperazin-1-yl)-N-(3-iodo-4-methyl-phenyl)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanecarboxylic acid | HCID 15655 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | N-(3-Iodo-4-methyl-phenyl)-6-piperazin-1-yl-nicotinamide | HCID 59318071 | — |
| Reactant | 4-{4-[5-(3-tert-Butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carbonyl}-cyclohexanecarboxylic acid methyl ester | HCID 59318085 | — |
| Product | 6-(4-Cyclopropanecarbonyl-piperazin-1-yl)-N-(3-iodo-4-methyl-phenyl)-nicotinamide | HCID 59318119 | — |
Reaction Steps
6-(4-Cyclopropanecarbonyl-piperazin-1-yl)-N-(3-iodo-4-methyl-phenyl)-nicotinamide was synthesized by the EDCI coupling of N-(3-iodo-4-methyl-phenyl)-6-piperazin-1-yl-nicotinamide and cyclopropanecarboxylic acid in a manner similar to the one described in the synthesis of 4-{4-[5-(3-tert-butyl-phenylcarbamoyl)-pyridin-2-yl]-piperazine-1-carbonyl}-cyclohexanecarboxylic acid methyl ester, above. LCMS calcd for C21H23IN4O2 (m/e) 490, obsd 491 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324385B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-e50546d5b8594519b553209bf1459602 |
| Source note | uspto-grants-2012_12 |