HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 219067Generated: October 26, 2026
Ammonia → 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine
https://huagongshe.com/reaction/219067
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | (+-)-2-Butanol | HCID 6568 | — |
| Reactant | (6-(3-Methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanamine | HCID 57691076 | — |
| Reactant | 8-Chloro-3-methoxy-1,5-naphthyridine | HCID 59427340 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 7-methoxy-N-((6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)-1,5-naphthyridin-4-amine | HCID 45487870 | 80% |
Reaction Steps
(6-(3-methylisothiazol-5-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methanamine (548 mg, 2225 μmol) and 8-chloro-3-methoxy-1,5-naphthyridine (576 mg, 2959 μmol) were charged in a microwave vial. 2-butanol (7 mL) was added and the reaction mixture was stirred at 120° C. under micro-waves irradiation for 8 h. 2M NH3 in MeOH was added. Purification by MPLC (DCM/MeOH+1% NH4OH: 100/0 to 90/10) afforded the title compound (720 mg, 80% yield). MS m/z=405.1 [M+H]+. Calc'd for C19H16N8OS: 404.46
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08198448B2 |
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| Source dataset | uspto-grants-2012_06 |
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| ORD ID | ord-64ba0988fcde40babf253c34bdedca05 |
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| Source note | uspto-grants-2012_06 |
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